| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of General and Environmental Physiology (G.V., G.P., G.T., M.C., M.S.) and Centro di Eccellenza in Genomica Comparata (G.V., M.S.), University of Bari, 70126 Bari, Italy
Address all correspondence and requests for reprints to: Dr. Giovanna Valenti, Department of General and Environmental Physiology, Via Amendola 165/A, 70126 Bari, Italy. E-mail: g.valenti{at}biologia.uniba.it.
In the kidney aquaporin-2 (AQP2) provides a target for hormonal regulation of water transport by vasopressin. Short-term control of water permeability occurs via vesicular trafficking of AQP2 and long-term control through changes in the abundance of AQP2 and AQP3 water channels. Defective AQP2 trafficking causes nephrogenic diabetes insipidus, a condition characterized by the kidney inability to produce concentrated urine because of the insensitivity of the distal nephron to vasopressin. AQP2 is redistributed to the apical membrane of collecting duct cells through activation of a cAMP signaling cascade initiated by the binding of vasopressin to its V2-receptor. Protein kinase A-mediated phosphorylation of AQP2 has been proposed to be essential in regulating AQP2-containing vesicle exocytosis. Cessation of the stimulus is followed by endocytosis of the AQP2 proteins exposed on the plasma membrane and their recycling to the original stores, in which they are retained. Soluble N-ethylmaleimide sensitive fusion factor attachment protein receptors (SNARE) and actin cytoskeleton organization regulated by small GTPase of the Rho family were also proved to be essential for AQP2 trafficking. Data for functional involvement of the SNARE vesicle-associated membrane protein 2 in AQP2 targeting has recently been provided. Changes in AQP2 expression/trafficking are of particular importance in pathological conditions characterized by both dilutional and concentrating defects. One of these conditions, hypercalciuria, has shown to be associated with alteration of AQP2 urinary excretion. More precisely, recent data support the hypothesis that, in vivo external calcium, through activation of calcium-sensing receptors, modulates the expression/trafficking of AQP2. Together these findings underscore the importance of AQP2 in kidney pathophysiology.
This article has been cited by other articles:
 |
|
 |
|
  J. Klokkers, P. Langehanenberg, B. Kemper, S. Kosmeier, G. von Bally, C. Riethmuller, F. Wunder, A. Sindic, H. Pavenstadt, E. Schlatter, et al. Atrial natriuretic peptide and nitric oxide signaling antagonizes vasopressin-mediated water permeability in inner medullary collecting duct cells Am J Physiol Renal Physiol, September 1, 2009; 297(3): F693 - F703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Kim, S.-H. Park, Y. W. Moon, S. Hwang, D. Kim, S.-H. Jo, S. B. Oh, J. S. Kim, J. W. Jahng, J.-H. Lee, et al. Histamine H1 Receptor Induces Cytosolic Calcium Increase and Aquaporin Translocation in Human Salivary Gland Cells J. Pharmacol. Exp. Ther., August 1, 2009; 330(2): 403 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Hasler, V. Leroy, P.-Y. Martin, and E. Feraille Aquaporin-2 abundance in the renal collecting duct: new insights from cultured cell models Am J Physiol Renal Physiol, July 1, 2009; 297(1): F10 - F18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Hoffert, C.-L. Chou, and M. A. Knepper Aquaporin-2 in the "-omics" Era J. Biol. Chem., May 29, 2009; 284(22): 14683 - 14687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Hasler Controlled aquaporin-2 expression in the hypertonic environment Am J Physiol Cell Physiol, April 1, 2009; 296(4): C641 - C653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Spring, S. R. Robichaux, and J. A. Hamlin The role of aquaporins in excretion in insects J. Exp. Biol., February 1, 2009; 212(3): 358 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Abramowitz and L. Birnbaumer Physiology and pathophysiology of canonical transient receptor potential channels FASEB J, February 1, 2009; 23(2): 297 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Padia, B. A. Kemp, N. L. Howell, J. J. Gildea, S. R. Keller, and R. M. Carey Intrarenal Angiotensin III Infusion Induces Natriuresis and Angiotensin Type 2 Receptor Translocation in Wistar-Kyoto but not in Spontaneously Hypertensive Rats Hypertension, February 1, 2009; 53(2): 338 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Butterworth, R. S. Edinger, R. A. Frizzell, and J. P. Johnson Regulation of the epithelial sodium channel by membrane trafficking Am J Physiol Renal Physiol, January 1, 2009; 296(1): F10 - F24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Nunes, U. Hasler, M. McKee, H. A. J. Lu, R. Bouley, and D. Brown A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2 Am J Physiol Cell Physiol, December 1, 2008; 295(6): C1476 - C1487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kong, Z. Zhang, D. Li, K. E. Wong, Y. Zhang, F. L. Szeto, M. W. Musch, and Y. C. Li Loss of Vitamin D Receptor Produces Polyuria by Increasing Thirst J. Am. Soc. Nephrol., December 1, 2008; 19(12): 2396 - 2405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Hasler, P. Nunes, R. Bouley, H. A. J. Lu, T. Matsuzaki, and D. Brown Acute Hypertonicity Alters Aquaporin-2 Trafficking and Induces a MAPK-dependent Accumulation at the Plasma Membrane of Renal Epithelial Cells J. Biol. Chem., September 26, 2008; 283(39): 26643 - 26661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Yu, T. Pisitkun, G. Wang, J. F. Aranda, P. A. Gonzales, D. Tchapyjnikov, R.-F. Shen, M. A. Alonso, and M. A. Knepper Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct Am J Physiol Cell Physiol, September 1, 2008; 295(3): C661 - C678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Noda, S. Horikawa, E. Kanda, M. Yamashita, H. Meng, K. Eto, Y. Li, M. Kuwahara, K. Hirai, C. Pack, et al. Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking J. Cell Biol., August 11, 2008; 182(3): 587 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Procino, C. Barbieri, G. Tamma, L. De Benedictis, J. E. Pessin, M. Svelto, and G. Valenti AQP2 exocytosis in the renal collecting duct - involvement of SNARE isoforms and the regulatory role of Munc18b J. Cell Sci., June 15, 2008; 121(12): 2097 - 2106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Uawithya, T. Pisitkun, B. E. Ruttenberg, and M. A. Knepper Transcriptional profiling of native inner medullary collecting duct cells from rat kidney Physiol Genomics, January 17, 2008; 32(2): 229 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. VanHouten, M. C. Neville, and J. J. Wysolmerski The Calcium-Sensing Receptor Regulates Plasma Membrane Calcium Adenosine Triphosphatase Isoform 2 Activity in Mammary Epithelial Cells: A Mechanism for Calcium-Regulated Calcium Transport into Milk Endocrinology, December 1, 2007; 148(12): 5943 - 5954. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chassin, M. W. Hornef, M. Bens, M. Lotz, J.-M. Goujon, S. Vimont, G. Arlet, A. Hertig, E. Rondeau, and A. Vandewalle Hormonal control of the renal immune response and antibacterial host defense by arginine vasopressin J. Exp. Med., November 26, 2007; 204(12): 2837 - 2852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Goel, W. G. Sinkins, C.-D. Zuo, U. Hopfer, and W. P. Schilling Vasopressin-induced membrane trafficking of TRPC3 and AQP2 channels in cells of the rat renal collecting duct Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1476 - F1488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. J. Lu, T.-X. Sun, T. Matsuzaki, X.-H. Yi, J. Eswara, R. Bouley, M. McKee, and D. Brown Heat Shock Protein 70 Interacts with Aquaporin-2 and Regulates Its Trafficking J. Biol. Chem., September 28, 2007; 282(39): 28721 - 28732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vossenkamper, P. I. Nedvetsky, B. Wiesner, J. Furkert, W. Rosenthal, and E. Klussmann Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells Am J Physiol Cell Physiol, September 1, 2007; 293(3): C1129 - C1138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Laxman and J. A. Beavo Cyclic Nucleotide Signaling Mechanisms in Trypanosomes: Possible Targets for Therapeutic Agents Mol. Interv., August 1, 2007; 7(4): 203 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Shen, M.-J. Lin, A. Yaradanakul, V. Lariccia, J. A. Hill, and D. W. Hilgemann Dual control of cardiac Na+ Ca2+ exchange by PIP2: analysis of the surface membrane fraction by extracellular cysteine PEGylation J. Physiol., August 1, 2007; 582(3): 1011 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. Shi, X. R. Cao, J. Qu, K. A. Volk, P. Kirby, R. A. Williamson, J. B. Stokes, and B. Yang Nephrogenic diabetes insipidus in mice caused by deleting COOH-terminal tail of aquaporin-2 Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1334 - F1344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Tamma, G. Procino, A. Strafino, E. Bononi, G. Meyer, M. Paulmichl, V. Formoso, M. Svelto, and G. Valenti Hypotonicity Induces Aquaporin-2 Internalization and Cytosol-to-Membrane Translocation of ICln in Renal Cells Endocrinology, March 1, 2007; 148(3): 1118 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Gardner, A. P. Naren, and S. W. Bahouth Assembly of an SAP97-AKAP79-cAMP-dependent Protein Kinase Scaffold at the Type 1 PSD-95/DLG/ZO1 Motif of the Human beta1-Adrenergic Receptor Generates a Receptosome Involved in Receptor Recycling and Networking J. Biol. Chem., February 16, 2007; 282(7): 5085 - 5099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-J. Yu, T. Pisitkun, G. Wang, R.-F. Shen, and M. A. Knepper LC-MS/MS Analysis of Apical and Basolateral Plasma Membranes of Rat Renal Collecting Duct Cells Mol. Cell. Proteomics, November 1, 2006; 5(11): 2131 - 2145. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
