This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Olsson, B. Articles by Oscarsson, J. Search for Related Content PubMed PubMed Citation Articles by Olsson, B. Articles by Oscarsson, J.

Bovine Growth Hormone Transgenic Mice Are Resistant to Diet-Induced Obesity but Develop Hyperphagia, Dyslipidemia, and Diabetes on a High-Fat Diet

Department of Physiology (B.O., M.B.-Y., S.M.F., F.F., A.L., J.T., G.B., J.O.), Göteborg University, S-405 30 Göteborg, Sweden; Department of Internal Medicine (B.O., M.B.-Y., J.T.), Division of Endocrinology, Wallenberg Laboratory for Cardiovascular Research (A.L., J.O.), Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden; Department of Medicine (B.A.), Lund University, S-22184 Lund, Sweden; and AstraZeneca R&D (M.B., F.F., J.T., J.O.), S-43183 Mölndal, Sweden

Address all correspondence and requests for reprints to: Bob Olsson, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg University, Vita Stråket 12, S-413 45 Göteborg, Sweden. E-mail: bob.olsson{at}medic.gu.se.

It is known that bovine GH (bGH) transgenic mice have increased body mass, insulin resistance, and altered lipoprotein metabolism when fed a normal diet (ND). In this study, the effects of 8 wk of high-fat diet (HFD) were investigated in 6-month-old male bGH mice. Although littermate controls had unchanged energy intake, energy intake was higher in the bGH mice on a HFD than on a low-fat diet. Nevertheless, the bGH mice were resistant to diet-induced weight gain, and only in the bGH mice did the HFD result in increased energy expenditure. Glucose oxidation was higher in the bGH mice compared with littermate controls on both a HFD and ND. In addition, the bGH mice had 0.5 C higher body temperature throughout the day and increased hepatic uncoupling protein 2 expression; changes that were unaffected by the HFD. On a HFD, the effect of bGH overexpression on serum triglycerides and apolipoprotein B was opposite to that on a ND, resulting in higher serum concentrations of triglycerides and apolipoprotein B compared with littermate controls. Increased serum triglycerides were explained by decreased triglyceride clearance. The HFD led to diabetes only in the bGH mice. In conclusion, bGH transgenic mice were resistant to diet-induced obesity despite hyperphagia, possibly due to increased energy expenditure. On a HFD, bGH mice became dyslipidemic and diabetic and thereby more accurately reflect the metabolic situation in acromegalic patients.

This article has been cited by other articles:

				A. J. Palmer, M.-Y. Chung, E. O. List, J. Walker, S. Okada, J. J. Kopchick, and D. E. Berryman Age-Related Changes in Body Composition of Bovine Growth Hormone Transgenic Mice Endocrinology, March 1, 2009; 150(3): 1353 - 1360. [Abstract] [Full Text] [PDF]

				J.-P. del Rincon, K. Iida, B. D. Gaylinn, C. E. McCurdy, J. W. Leitner, L. A. Barbour, J. J. Kopchick, J. E. Friedman, B. Draznin, and M. O. Thorner Growth Hormone Regulation of p85{alpha} Expression and Phosphoinositide 3-Kinase Activity in Adipose Tissue: Mechanism for Growth Hormone-Mediated Insulin Resistance Diabetes, June 1, 2007; 56(6): 1638 - 1646. [Abstract] [Full Text] [PDF]

				J. D. McKay, R. Kaaks, M. Johansson, C. Biessy, F. Wiklund, K. Balter, H.-O. Adami, C. Boillot, L. Gioia-Patricola, F. Canzian, et al. Haplotype-Based Analysis of Common Variation in the Growth Hormone Receptor Gene and Prostate Cancer Risk Cancer Epidemiol. Biomarkers Prev., January 1, 2007; 16(1): 169 - 173. [Abstract] [Full Text] [PDF]

				D. E. Berryman, E. O. List, D. T. Kohn, K. T. Coschigano, R. J. Seeley, and J. J. Kopchick Effect of Growth Hormone on Susceptibility to Diet-Induced Obesity Endocrinology, June 1, 2006; 147(6): 2801 - 2808. [Abstract] [Full Text] [PDF]

				M. C. Garcia, I. Wernstedt, A. Berndtsson, M. Enge, M. Bell, O. Hultgren, M. Horn, B. Ahren, S. Enerback, C. Ohlsson, et al. Mature-onset obesity in interleukin-1 receptor I knockout mice. Diabetes, May 1, 2006; 55(5): 1205 - 1213. [Abstract] [Full Text] [PDF]

				C. Z. Michaylira, N. M. Ramocki, J. G. Simmons, C. K. Tanner, K. K. McNaughton, J. T. Woosley, C. J. Greenhalgh, and P. K. Lund Haplotype Insufficiency for Suppressor of Cytokine Signaling-2 Enhances Intestinal Growth and Promotes Polyp Formation in Growth Hormone-Transgenic Mice Endocrinology, April 1, 2006; 147(4): 1632 - 1641. [Abstract] [Full Text] [PDF]