This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sun, L. Y. Articles by Bartke, A. Search for Related Content PubMed PubMed Citation Articles by Sun, L. Y. Articles by Bartke, A. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Compound via MeSH Substance via MeSH Medline Plus Health Information Dwarfism

Increased Neurogenesis in Dentate Gyrus of Long-Lived Ames Dwarf Mice

Geriatrics Research (L.Y.S., J.P., A.B.), Department of Internal Medicine (L.Y.S., J.P., A.B.), Department of Physiology (L.Y.S., A.B.), and Department of Neurology (S.E.), Southern Illinois University School of Medicine, Springfield, Illinois 62794; and Laboratory of Genetics (J.H.), The Salk Institute, La Jolla, California 92037

Address all correspondence and requests for reprints to: Dr. Andrzej Bartke, Southern Illinois University, School of Medicine, Department of Internal Medicine-Geriatrics Research, Room 4389, 801 North Rutledge, Springfield, Illinois 62794-9628. E-mail: abartke{at}siumed.edu.

Neurogenesis occurs throughout adult life in the dentate gyrus of mammalian hippocampus and has been suggested to play an important role in cognitive function. Multiple trophic factors including IGF-I have been demonstrated to regulate hippocampal neurogenesis. Ames dwarf mice live considerably longer than normal animals and maintain physiological function at youthful levels, including cognitive function, despite a deficiency of circulating GH and IGF-I. Here we show an increase in numbers of newly generated cells [bromodeoxyuridine (BrdU) positive] and newborn neurons (neuronal nuclear antigen and BrdU positive) in the dentate gyrus of adult dwarf mice compared with normal mice using BrdU labeling. Despite the profound suppression of hippocampal GH expression, hippocampal IGF-I protein levels are up-regulated and the corresponding mRNAs are as high in Ames dwarf as in normal mice. Our results suggest that local/hippocampal IGF-I expression may have induced the increase in hippocampal neurogenesis, and increased neurogenesis might contribute to the maintenance of youthful levels of cognitive function during aging in these long-lived animals.

This article has been cited by other articles:

				D. Drummond-Barbosa Stem Cells, Their Niches and the Systemic Environment: An Aging Network Genetics, December 1, 2008; 180(4): 1787 - 1797. [Abstract] [Full Text] [PDF]

				L. Y. Sun and A. Bartke Adult Neurogenesis in the Hippocampus of Long-Lived Mice During Aging J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2007; 62(2): 117 - 125. [Abstract] [Full Text] [PDF]

				L. Y. Sun and A. J. D'Ercole Insulin-Like Growth Factor-I Stimulates Histone H3 and H4 Acetylation in the Brain in Vivo Endocrinology, November 1, 2006; 147(11): 5480 - 5490. [Abstract] [Full Text] [PDF]

				V. C. Russo, P. D. Gluckman, E. L. Feldman, and G. A. Werther The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain Endocr. Rev., December 1, 2005; 26(7): 916 - 943. [Abstract] [Full Text] [PDF]

				A. Bartke Minireview: Role of the Growth Hormone/Insulin-Like Growth Factor System in Mammalian Aging Endocrinology, September 1, 2005; 146(9): 3718 - 3723. [Abstract] [Full Text] [PDF]

				M. Leslie Young at Brain Sci. Aging Knowl. Environ., December 8, 2004; 2004(49): nf108 - nf108. [Abstract] [Full Text]