help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology, doi:10.1210/en.2004-1179
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Heuer, H.
Right arrow Articles by Bauer, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Heuer, H.
Right arrow Articles by Bauer, K.
Endocrinology Vol. 146, No. 4 1701-1706
Copyright © 2005 by The Endocrine Society

The Monocarboxylate Transporter 8 Linked to Human Psychomotor Retardation Is Highly Expressed in Thyroid Hormone-Sensitive Neuron Populations

Heike Heuer, Michael K. Maier, Sandra Iden, Jens Mittag, Edith C. H. Friesema, Theo J. Visser and Karl Bauer

Max Planck Institute for Experimental Endocrinology (H.H., M.K.M., S.I., J.M., K.B.), D-30625 Hannover, Germany; Institute of Molecular Biotechnology (H.H.), D-07745 Jena, Germany; and Department of Internal Medicine, Erasmus Medical Center (E.C.H.F., T.J.V.), 3015 GE Rotterdam, The Netherlands

Address all correspondence and requests for reprints to: Dr. Heike Heuer, Institute of Molecular Biotechnology, Beutenbergstrasse 11, D-07745 Jena, Germany. E-mail: hheuer{at}imb-jena.de.

Recent genetic analysis in several patients presenting a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels have revealed mutations or deletions in the gene of the monocarboxylate transporter 8 (MCT8). Because in vitro MCT8 functions as a TH transporter, the complex clinical picture of these patients indicated an important role for MCT8 in TH-dependent processes of brain development. To provide a clue to the cellular function of MCT8 in brain, we studied the expression of MCT8 mRNA in the murine central nervous system by in situ hybridization histochemistry. In addition to the choroid plexus structures, the highest transcript levels were found in neo- and allocortical regions (e.g. olfactory bulb, cerebral cortex, hippocampus, and amygdala), moderate signal intensities in striatum and cerebellum, and low levels in a few neuroendocrine nuclei. Colocalization studies revealed that MCT8 is predominantly expressed in neurons. Together with the spatiotemporal expression pattern of MCT8 during the perinatal period, these results strongly indicate that MCT8 plays an important role for proper central nervous system development by transporting TH into neurons as its main target cells.




This article has been cited by other articles:


Home page
 J Mol EndocrinolHome page
A. Kinne, S. Roth, H. Biebermann, J. Kohrle, A. Gruters, and U. Schweizer
Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent
J. Mol. Endocrinol., December 1, 2009; 43(6): 263 - 271.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. K. Wirth, S. Roth, C. Blechschmidt, S. M. Holter, L. Becker, I. Racz, A. Zimmer, T. Klopstock, V. Gailus-Durner, H. Fuchs, et al.
Neuronal 3',3,5-Triiodothyronine (T3) Uptake and Behavioral Phenotype of Mice Deficient in Mct8, the Neuronal T3 Transporter Mutated in Allan-Herndon-Dudley Syndrome
J. Neurosci., July 29, 2009; 29(30): 9439 - 9449.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Vujovic, K. Nordstrom, K. Gauthier, F. Flamant, T. J. Visser, B. Vennstrom, and J. Mittag
Interference of a Mutant Thyroid Hormone Receptor {alpha}1 with Hepatic Glucose Metabolism
Endocrinology, June 1, 2009; 150(6): 2940 - 2947.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. R. Vella and A. N. Hollenberg
The Ups and Downs of Thyrotropin-Releasing Hormone
Endocrinology, May 1, 2009; 150(5): 2021 - 2023.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Ceballos, M. M. Belinchon, E. Sanchez-Mendoza, C. Grijota-Martinez, A. M. Dumitrescu, S. Refetoff, B. Morte, and J. Bernal
Importance of Monocarboxylate Transporter 8 for the Blood-Brain Barrier-Dependent Availability of 3,5,3'-Triiodo-L-Thyronine
Endocrinology, May 1, 2009; 150(5): 2491 - 2496.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. Sanchez, M. A. Vargas, P. S. Singru, I. Pascual, F. Romero, C. Fekete, J.-L. Charli, and R. M. Lechan
Tanycyte Pyroglutamyl Peptidase II Contributes to Regulation of the Hypothalamic-Pituitary-Thyroid Axis through Glial-Axonal Associations in the Median Eminence
Endocrinology, May 1, 2009; 150(5): 2283 - 2291.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Herwig, D. Wilson, T. J. Logie, A. Boelen, P. J. Morgan, J. G. Mercer, and P. Barrett
Photoperiod and acute energy deficits interact on components of the thyroid hormone system in hypothalamic tanycytes of the Siberian hamster
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1307 - R1315.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. R. James, J. A. Franklyn, B. J. Reaves, V. E. Smith, S. Y. Chan, T. G. Barrett, M. D. Kilby, and C. J. McCabe
Monocarboxylate Transporter 8 in Neuronal Cell Growth
Endocrinology, April 1, 2009; 150(4): 1961 - 1969.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Heuer and T. J. Visser
Pathophysiological Importance of Thyroid Hormone Transporters
Endocrinology, March 1, 2009; 150(3): 1078 - 1083.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. M. Roberts, K. Woodford, M. Zhou, D. S. Black, J. E. Haggerty, E. H. Tate, K. K. Grindstaff, W. Mengesha, C. Raman, and N. Zerangue
Expression of the Thyroid Hormone Transporters Monocarboxylate Transporter-8 (SLC16A2) and Organic Ion Transporter-14 (SLCO1C1) at the Blood-Brain Barrier
Endocrinology, December 1, 2008; 149(12): 6251 - 6261.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
W. M. van der Deure, P. S. Hansen, R. P. Peeters, K. O. Kyvik, E. C. H. Friesema, L. Hegedus, and T. J. Visser
Thyroid Hormone Transport and Metabolism by Organic Anion Transporter 1C1 and Consequences of Genetic Variation
Endocrinology, October 1, 2008; 149(10): 5307 - 5314.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. C. H. Friesema, J. Jansen, J.-w. Jachtenberg, W. E. Visser, M. H. A. Kester, and T. J. Visser
Effective Cellular Uptake and Efflux of Thyroid Hormone by Human Monocarboxylate Transporter 10
Mol. Endocrinol., June 1, 2008; 22(6): 1357 - 1369.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Jansen, E. C. H. Friesema, M. H. A. Kester, C. E. Schwartz, and T. J. Visser
Genotype-Phenotype Relationship in Patients with Mutations in Thyroid Hormone Transporter MCT8
Endocrinology, May 1, 2008; 149(5): 2184 - 2190.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. Sanchez, P. S. Singru, C. Fekete, and R. M. Lechan
Induction of Type 2 Iodothyronine Deiodinase in the Mediobasal Hypothalamus by Bacterial Lipopolysaccharide: Role of Corticosterone
Endocrinology, May 1, 2008; 149(5): 2484 - 2493.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Lamirand, G. Mercier, M. Ramauge, M. Pierre, and F. Courtin
Hypoxia Stabilizes Type 2 Deiodinase Activity in Rat Astrocytes
Endocrinology, October 1, 2007; 148(10): 4745 - 4753.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. A. Galton, E. T. Wood, E. A. St. Germain, C.-A. Withrow, G. Aldrich, G. M. St. Germain, A. S. Clark, and D. L. St. Germain
Thyroid Hormone Homeostasis and Action in the Type 2 Deiodinase-Deficient Rodent Brain during Development
Endocrinology, July 1, 2007; 148(7): 3080 - 3088.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Jansen, E. C. H. Friesema, M. H. A. Kester, C. Milici, M. Reeser, A. Gruters, T. G. Barrett, E. E. Mancilla, J. Svensson, J.-L. Wemeau, et al.
Functional Analysis of Monocarboxylate Transporter 8 Mutations Identified in Patients with X-Linked Psychomotor Retardation and Elevated Serum Triiodothyronine
J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2378 - 2381.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Roos, S. J. L. Bakker, T. P. Links, R. O. B. Gans, and B. H. R. Wolffenbuttel
Thyroid Function Is Associated with Components of the Metabolic Syndrome in Euthyroid Subjects
J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 491 - 496.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. C. H. Friesema, G. G. J. M. Kuiper, J. Jansen, T. J. Visser, and M. H. A. Kester
Thyroid Hormone Transport by the Human Monocarboxylate Transporter 8 and Its Rate-Limiting Role in Intracellular Metabolism
Mol. Endocrinol., November 1, 2006; 20(11): 2761 - 2772.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Bernal
Role of Monocarboxylate Anion Transporter 8 (MCT8) in Thyroid Hormone Transport: Answers from Mice.
Endocrinology, September 1, 2006; 147(9): 4034 - 4035.
[Full Text] [PDF]

Home page
 J EndocrinolHome page
A. G. Trentin
Thyroid hormone and astrocyte morphogenesis.
J. Endocrinol., May 1, 2006; 189(2): 189 - 197.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. J. Visser
The elemental importance of sufficient iodine intake: a trace is not enough.
Endocrinology, May 1, 2006; 147(5): 2095 - 2097.
[Full Text] [PDF]

Home page
 J. Med. Genet.Home page
C M C Maranduba, E C H Friesema, F Kok, M H A Kester, J Jansen, A L Sertie, M R Passos-Bueno, and T J Visser
Decreased cellular uptake and metabolism in Allan-Herndon-Dudley syndrome (AHDS) due to a novel mutation in the MCT8 thyroid hormone transporter
J. Med. Genet., May 1, 2006; 43(5): 457 - 460.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Bernal
The Significance of Thyroid Hormone Transporters in the Brain
Endocrinology, April 1, 2005; 146(4): 1698 - 1700.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2005 by The Endocrine Society