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Molecular Endocrinology Group (P.B., A.W.R., A.B., P.A.L., J.G.M., K.M.M., C.U., P.J.M.), Rowett Research Institute and Aberdeen Centre for Energy Regulation and Obesity, Aberdeen AB21 9SB, Scotland, United Kingdom; Department of Biology (T.S., J.K., P.P.), Åbo Akademi University, Artillerigatan 6 20520, Åbo, Finland; Neuroscience Center (P.P.), Institute of Biomedicine/Anatomy, University of Helsinki, 00290 Helsinki, Finland; and School of Biomedical Sciences (S.S., F.J.E.), University of Nottingham Medical School, Nottingham NG7 2UH, United Kingdom
Address all correspondence and requests for reprints to: Dr. Perry Barrett, Molecular Endocrinology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, United Kingdom. E mail: pb{at}rri.sari.ac.uk.
To survive winter the Siberian hamster has evolved profound physiological and behavioral adaptations, including a moult to winter pelage, regression of the reproductive axis, onset of daily torpor and increased capacity for thermogenesis. However, one of the most striking adaptations is the catabolism of intraabdominal and sc fat reserves contributing to the loss of up to 40% of body weight. These physiological and behavioral adaptations are photoperiodically driven, yet neither the site(s) in the brain nor the molecular mechanism(s) involved in the regulation of these profound adaptations is known. Here we report a dynamic regulation of gene expression in a dorsal region of the medial posterior area of the arcuate nucleus (dmpARC) of the Siberian and Syrian hamster brain in response to altered photoperiod. We show mRNA for the histamine H3 receptor is down-regulated and VGF is up-regulated in the dmpARC in hamsters switched from long- to short-day photoperiod. These data provide further evidence to support the view that the dmpARC is a major site to relay photoperiodic changes and as a site for the long-term regulation of seasonal physiology and behavior.
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P. H. Jethwa, A. Warner, K. N. Nilaweera, J. M. Brameld, J. W. Keyte, W. G. Carter, N. Bolton, M. Bruggraber, P. J. Morgan, P. Barrett, et al. VGF-Derived Peptide, TLQP-21, Regulates Food Intake and Body Weight in Siberian Hamsters Endocrinology, August 1, 2007; 148(8): 4044 - 4055. [Abstract] [Full Text] [PDF]
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P. Barrett, F. J. P. Ebling, S. Schuhler, D. Wilson, A. W. Ross, A. Warner, P. Jethwa, A. Boelen, T. J. Visser, D. M. Ozanne, et al. Hypothalamic Thyroid Hormone Catabolism Acts as a Gatekeeper for the Seasonal Control of Body Weight and Reproduction Endocrinology, August 1, 2007; 148(8): 3608 - 3617. [Abstract] [Full Text] [PDF]
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T. Watanabe, T. Yamamura, M. Watanabe, S. Yasuo, N. Nakao, A. Dawson, S. Ebihara, and T. Yoshimura Hypothalamic expression of thyroid hormone-activating and -inactivating enzyme genes in relation to photorefractoriness in birds and mammals Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R568 - R572. [Abstract] [Full Text] [PDF]
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 M. Canonaco, M. Madeo, R. Alo, G. Giusi, T. Granata, A. Carelli, A. Canonaco, and R. M. Facciolo The Histaminergic Signaling System Exerts a Neuroprotective Role against Neurodegenerative-Induced Processes in the Hamster J. Pharmacol. Exp. Ther., October 1, 2005; 315(1): 188 - 195. [Abstract] [Full Text] [PDF]
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G. A. Lincoln, J. D. Johnston, H. Andersson, G. Wagner, and D. G. Hazlerigg Photorefractoriness in Mammals: Dissociating a Seasonal Timer from the Circadian-Based Photoperiod Response Endocrinology, September 1, 2005; 146(9): 3782 - 3790. [Abstract] [Full Text] [PDF]
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A. W. Ross, L. M. Bell, P. A. Littlewood, J. G. Mercer, P. Barrett, and P. J. Morgan Temporal Changes in Gene Expression in the Arcuate Nucleus Precede Seasonal Responses in Adiposity and Reproduction Endocrinology, April 1, 2005; 146(4): 1940 - 1947. [Abstract] [Full Text] [PDF]
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