This Article Full Text Full Text (PDF) All Versions of this Article: 146/5/2193    most recent Author Manuscript (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by la Fleur, S. E. Articles by Dallman, M. F. Search for Related Content PubMed PubMed Citation Articles by la Fleur, S. E. Articles by Dallman, M. F.

Choice of Lard, But Not Total Lard Calories, Damps Adrenocorticotropin Responses to Restraint

Department of Physiology, University of California San Francisco, San Francisco, California 94143-0444

Address all correspondence and requests for reprints to: Mary F. Dallman, Department of Physiology, University of California San Francisco, San Francisco, California 94143-0444. E-mail: dallman{at}itsa.ucsf.edu.

Although rats given the choice of eating high-density calories as concentrated sucrose solutions or lard exhibit reduced responsivity in the hypothalamo-pituitary-adrenal axis, rats fed high-fat diets have normal or augmented responses to stressors. To resolve this apparent discrepancy, we compared in adult male rats the effects of 7-d feeding with lard + chow (choice) to feeding a 50% lard-chow mixture (no-choice) and to chow only. Rats with choice composed diets with 50–60% total calories from lard. Rats were exposed to 30 min of restraint on d 7. In the choice group, there was a robust inhibition of ACTH and corticosterone responses to restraint compared with chow or no-choice groups. Total caloric intake was less with choice than no-choice. Fat depot weights and body weight gain were similar in the high-fat groups. Leptin concentrations were equal but insulin was higher in the choice group. We conclude the following: 1) choice of eating high-density calories strongly damps hypothalamo-pituitary-adrenal responses to stress; without choice, high-density diet is ineffective; and 2) insulin may signal metabolic well-being, and may act through hypothalamic sites to reduce caloric intake but through forebrain sites to damp stress responses.

This article has been cited by other articles:

				M. F. Dallman, J. P. Warne, M. T. Foster, and N. C. Pecoraro Glucocorticoids and insulin both modulate caloric intake through actions on the brain J. Physiol., September 1, 2007; 583(2): 431 - 436. [Abstract] [Full Text] [PDF]

				J. P. Warne, M. T. Foster, H. F. Horneman, N. C. Pecoraro, A. B. Ginsberg, S. F. Akana, and M. F. Dallman Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats J. Physiol., September 1, 2007; 583(2): 455 - 467. [Abstract] [Full Text] [PDF]

				A. Legendre, E. Papakonstantinou, M.-C. Roy, D. Richard, and R. B. S. Harris Differences in response to corticotropin-releasing factor after short- and long-term consumption of a high-fat diet Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1076 - R1085. [Abstract] [Full Text] [PDF]

				J. P. Warne, M. T. Foster, H. F. Horneman, N. C. Pecoraro, A. B. Ginsberg, S. F. Akana, and M. F. Dallman Hepatic Branch Vagotomy, Like Insulin Replacement, Promotes Voluntary Lard Intake in Streptozotocin-Diabetic Rats Endocrinology, July 1, 2007; 148(7): 3288 - 3298. [Abstract] [Full Text] [PDF]

				Y. M. Ulrich-Lai, M. M. Ostrander, I. M. Thomas, B. A. Packard, A. R. Furay, C. M. Dolgas, D. C. Van Hooren, H. F. Figueiredo, N. K. Mueller, D. C. Choi, et al. Daily Limited Access to Sweetened Drink Attenuates Hypothalamic-Pituitary-Adrenocortical Axis Stress Responses Endocrinology, April 1, 2007; 148(4): 1823 - 1834. [Abstract] [Full Text] [PDF]

				J. P. Warne, H. F. Horneman, E. C. Wick, A. Bhargava, N. C. Pecoraro, A. B. Ginsberg, S. F. Akana, and M. F. Dallman Comparison of Superior Mesenteric Versus Jugular Venous Infusions of Insulin in Streptozotocin-Diabetic Rats on the Choice of Caloric Intake, Body Weight, and Fat Stores Endocrinology, November 1, 2006; 147(11): 5443 - 5451. [Abstract] [Full Text] [PDF]

				A. Legendre and R. B. S. Harris Exaggerated response to mild stress in rats fed high-fat diet Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1288 - 1294. [Abstract] [Full Text] [PDF]