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Endocrinology, doi:10.1210/en.2005-0502
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Endocrinology Vol. 146, No. 9 3926-3932
Copyright © 2005 by The Endocrine Society

The Telomerase Activity of Adult Mouse Testis Resides in the Spermatogonial {alpha}6-Integrin-Positive Side Population Enriched in Germinal Stem Cells

Lydia Riou, Henri Bastos, Bruno Lassalle, Mathieu Coureuil, Jacques Testart, François D. Boussin, Isabelle Allemand and Pierre Fouchet

Laboratoire Gamétogenèse, Apoptose et Génotoxicité/Institut National de la Santé et de la Recherche Médicale Unité 566 (L.R., H.B., B.L., M.C., J.T., I.A., P.F.), and Laboratoire de Radiopathologie (F.D.B.), Département de Radiobiologie et Radiopathologie, Direction des Sciences du Vivant, CEA, 92265 Fontenay aux Roses, France

Address all correspondence and requests for reprints to: Pierre Fouchet, Laboratoire Gamétogenèse, Apoptose et Génotoxicité (LGAG), DRR/DSV, CEA, 18 route du Panorama, 92265 Fontenay-aux-Roses, France. E-mail: pierre.fouchet{at}cea.fr.

Testis is one of the organs with the most telomerase activity in the adult. This activity protects chromosomes from telomere attrition and ensures the transmission of full-length chromosomes to progeny. Little is known about telomerase activity during adult germ cell differentiation, however. We demonstrate here that the telomerase activity of adult mouse testis resides in the {alpha}6-integrin-positive Side Population containing spermatogonia and enriched in spermatogonial stem cells. The telomerase activity of these cells fell upon entry into meiosis and during the subsequent spermiogenesis. In addition, the telomerase activity of cells in various stages of differentiation was unaffected by aging and, notably, remained high in the {alpha}6-integrin-positive Side Population.






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Copyright © 2005 by The Endocrine Society