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Minireview: Pharmacogenetics and Beyond: The Interaction of Therapeutic Response, ß-Cell Physiology, and Genetics in Diabetes

Peninsula Medical School (A.T.H., E.R.P.), Exeter EX2 5DW, United Kingdom; and Ninewells Hospital and Medical School (E.R.P.), Dundee DD1 9SY, Scotland, United Kingdom

Address all correspondence and requests for reprints to: Dr. Andrew T. Hattersley, Peninsula Medical School, Barrack Road, Exeter EX2 5DW, United Kingdom. Email: a.t.hattersley{at}exeter.ac.uk.

Defining the molecular genetics of diabetes gives new insight into the underlying etiology and so should help improve treatment. The genetic etiology is now known for most patients with ß-cell monogenic diabetes, allowing genetic classification. We review how this genetic knowledge alters treatment. Patients with a glucose-sensing ß-cell defect due to glucokinase mutations have regulated, mild, fasting hyperglycemia. Oral hypoglycemic agents or low-dose insulin rarely improve glycemic control. Patients with hepatic nuclear factor-1 (HNF1) mutations have progressive ß-cell deterioration and require treatment. HNF1 patients are 4 times more sensitive to sulfonylureas than matched type 2 diabetic patients. This is partly due to greater insulin secretion, reflecting the fact that the defect in HNF1 deficiency precedes the K_ATP channel where sulfonylureas act. HNF1ß is expressed in pancreatic stem cells before differentiation into endocrine or exocrine cells, so patients with HNF1ß mutations have reduced pancreatic development, resulting in early-onset diabetes and exocrine dysfunction. These patients usually rapidly require insulin and are not sensitive to sulfonylureas. Thirty-five to 50% of patients diagnosed with diabetes before 6 months have a mutation in Kir6.2. The mutated K_ATP channel in these patients does not close in response to increased ATP concentrations, but can be closed when sulfonylureas bind to the sulfonylurea receptor 1 subunit of the channel by an ATP-independent route. These patients are usually insulin dependent, but have excellent glycemic control on high-dose sulfonylureas tablets. In conclusion, the defining of molecular genetic etiology in monogenic diabetes has identified several specific ß-cell defects, and these are critical in determining the response to treatment.

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