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Minireview: Adenosine 5'-Monophosphate-Activated Protein Kinase Regulation of Fatty Acid Oxidation in Skeletal Muscle

Karolinska Institute, Department of Molecular Medicine and Surgery, Integrative Physiology, SE-171 77 Stockholm, Sweden

Address all correspondence and requests for reprints to: Juleen Zierath, Karolinska Institute, Department of Molecular Medicine and Surgery, Integrative Physiology, von Eulers väg 4, 4 SE-171 77 Stockholm, Sweden. E-mail: Juleen.Zierath{at}ki.se.

Abstract

AMP-activated protein kinase (AMPK) is master regulator of energy balance through suppression of ATP-consuming anabolic pathways and enhancement of ATP-producing catabolic pathways. AMPK is activated by external metabolic stresses and subsequently orchestrates a complex downstream signaling cascade that mobilizes the cell for efficient energy production. AMPK has emerged as a key kinase driving lipid oxidation in skeletal muscle, and this function has important implications for exercise adaptations as well as metabolic defects associated with obesity.