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Hormones and Mammary Cell Fate—What Will I Become When I Grow Up?

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030

Address all correspondence and requests for reprints to: Jeffrey M. Rosen, One Baylor Plaza, Department of Molecular and Cellular Biology, DeBakey Building M638a, Houston, Texas 77030. E-mail: jrosen{at}bcm.edu.

Systemic hormones are key regulators of postnatal mammary gland development and play an important role in the etiology and treatment of breast cancer. Mammary ductal morphogenesis is controlled by circulating hormones, and these same hormones are also critical mediators of mammary stem cell fate decisions. Recent studies have helped further our understanding of the origin, specification, and fate of mammary stem cells during postnatal development. Here we review recent studies on the involvement of hormone receptors and several transcription factors in mammary stem/progenitor cell differentiation and lineage commitment.

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