This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Palmer, A. J. Articles by Berryman, D. E. Search for Related Content PubMed PubMed Citation Articles by Palmer, A. J. Articles by Berryman, D. E. Pubmed/NCBI databases Gene GEO Profiles HomoloGene Protein UniGene Substance via MeSH Medline Plus Health Information Seniors' Health

Age-Related Changes in Body Composition of Bovine Growth Hormone Transgenic Mice

School of Human and Consumer Sciences (A.J.P., M.-Y.C., J.W., D.E.B.), College of Health and Human Services, Edison Biotechnology Institute (A.J.P., E.O.L., S.O., J.J.K.), and Departments of Pediatrics (S.O.), Biomedical Sciences (J.J.K.), College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701; and Department of Nutritional Science (M.-Y.C.), University of Connecticut, Storrs, Connecticut 06269

Address all correspondence and requests for reprints to: Darlene E. Berryman, Ph.D., R.D., L.D., W324 Grover Center, School of Human and Consumer Sciences, Ohio University, Athens, Ohio 45701. E-mail: berrymad{at}ohio.edu.

GH has a significant impact on body composition due to distinct anabolic and catabolic effects on lean and fat mass, respectively. Several studies have assessed body composition in mice expressing a GH transgene. Whereas all studies report enhanced growth of transgenic mice as compared with littermate controls, there are inconsistencies in terms of the relative proportion of lean mass to fat mass in these animals. The purpose of this study was to characterize the accumulation of adipose and lean mass with age and according to gender in a bovine (b) GH transgenic mouse line. Weight and body composition measurements were assessed in male and female bGH mice with corresponding littermate controls in the C57BL/6J genetic background. Body composition measurements began at 6 wk and continued through 1 yr of age. At the conclusion of the study, tissue weights were determined and triglyceride content was quantified in liver and kidney. Although body weights for bGH mice were significantly greater than their corresponding littermate controls at all time points, body composition measurements revealed an unexpected transition midway through analyses. That is, younger bGH mice had relatively more fat mass than nontransgenic littermates, whereas bGH mice became significantly leaner than controls by 4 months in males and 6 months in females. These results reveal the importance in timing and gender when conducting studies related to body composition or lean and fat tissue in GH transgenic mice or in other genetically manipulated mouse strains in which body composition may be impacted.

This article has been cited by other articles:

				D. E. Berryman, E. O. List, A. J. Palmer, M.-Y. Chung, J. Wright-Piekarski, E. Lubbers, P. O'Connor, S. Okada, and J. J. Kopchick Two-Year Body Composition Analyses of Long-Lived GHR Null Mice J Gerontol A Biol Sci Med Sci, November 9, 2009; (2009) glp175v1. [Abstract] [Full Text] [PDF]