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CHEMICAL FRACTIONATION OF THE GONADO TROPIC FACTORS PRESENT IN SHEEP PITUITARY¹

the Institute of Experimental Biology, University of California BERKELEY, CALIFORNIA

Abstract

STUDY OF THE FUNCTIONAL interrelationship of the pituitary with the gonads has yielded a number of facts of great importance, but many features of the mechanism of this reciprocal relationship are still obscure. Some of the results secured are actually contradictory to others and the situation in general has permitted undesirable freedom in interpretation. Conceptions as to this interrelationship have also doubtless been complicated by the postulation of several different gonadotropic principles (1, 2, 3). A prime reason for failure in arriving at a clear understanding of how many specific gonadotropic principles are actually secreted by the pituitary is the difficulty of adequately purifying pituitary fractions so that they will have a specific effect on the gonads.

In our preliminary studies of the gonadotropic principles in the sheep pituitary, it became apparent that several different biological effects—syner-gism, luteinizfttion, and antagonism—were all given by the interstitial cell stimulating fraction when given in combination with the follicle stimulating fraction.

Footnotes

¹ This investigation was aided by grants from the Board of Research of the University of California and the Rockefeller Foundation of New York City.

² Research Associate, March ist-August 1st, 1937, by invitation; December 1st ’37-September 1st, ‘38, under a fellowship of E. R. Squibb and Sons. New York City. Squibb Institute for Medical Research, New Brunswick, New Jersey.

³ Squibb Institute for Medical Research, New Brunswick, New Jersey.

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				E. T. ENGLE and L. LEVIN GONADOTROPINS OF THE ANTERIOR LOBE OF THE PITUITARY AND OF CHORIONIC TISSUE JAMA, January 4, 1941; 116(1): 47 - 52. [Abstract] [PDF]

				E. H. RYNEARSON and L. R. SCHWEIGER REVIEW OF LITERATURE ON THE PITUITARY BODY (1938 AND 1939) Arch Intern Med, July 1, 1940; 66(1): 226 - 290. [Abstract] [PDF]