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TTHE INHIBITION OF COMB GROWTH IN COCKERELS AND CAPONS BY ESTRONEW^1,2,3

From the Department of Biochemistry, The University of Chicago CHICAGO, ILLINOIS

Abstract

A NTAGONISTIC as well as augmentative effects of the simultaneous ad'JLX. ministration of male and female sex hormones in mammals have been the subjects of numerous reports in the literature. The antagonistic effect is usually interpreted as an inhibition of the gonadotropic activity of the pituitary as suggested by Moore and Price (i), while the synergistic effects have not as yet been explained

In Brown Leghorn capons, Juhn, D'Amour and Womack (2) found neither an ntagonism nor an intensification of effect when purified testis'tissue concentrates (2, capon units per day) and a urinary estrogen preparation (150 R.U. per day) were injected simultaneously for 34 days. Juhn, Gustavson and Gallagher (3) administered urinary estrogenconcentrates (10 R.U. per 25 gm. body weight) to young cockerels of various ages and found no evidence of antagonism except a shrinkage of the comb in a few birds in the group 12weeks of age. Since the testes of these birds were normal histologically.

Footnotes

¹ These investigations were supported in part by a grant from the Rockefeller Foundation.

² The estrone used was supplied through the kindness of Dr. Cartland of the Upjohn Company, Kalama?oo, Michigan.

³ The androsterone was supplied through the kindness of Dr. Schwenk of the Schering Corporation, Bloomfield, New Jersey.