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A CASE OF ACROMEGALY STUDIED DURING THE COURSE OF THE DISEASE AND AT AUTOPSY

From the Third Medical Division, Bellevue Hospital and the Department of Medicine, New York University College of Medicine NEW YORK CITY

Abstract

SINCE THE monograph by Cushing and Davidoff (1) on acromegaly there have been only a few reports of this disease in which the clinical observations have been correlated with the autopsy findings (2, 3) as the patients are seldom seen terminally by those who have observed the case during life. The patient in this instance was seen 2 years after she had developed acromegaly and was followed in the hospital and clinic for the remaining 3 years of her life. During this time insulin sensitivity studies were made.

Acromegaly is one of the few well defined clinical conditions which can definitely be related to the hypersecretion of a hormone of the anterior pituitary. Furthermore, when injected into experimental animals, this hormone will produce the bony changes characteristic of the disease (4). Accompanying the bony changes there are other changes which may or may not occur in patients with acromegaly.