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THE SUGAR UTILIZATION OFHYPOPHYSECTOMIZED RABBITS

From the Department of Physiology, School of Medicine, University of Southern California LOS ANGELES, CALIFORNIA

Abstract

THE TENDENCY to hypoglycemia of a fasted hypophysectomized animal has been abundantly demonstrated (1 – 2). In the rat the cause of this hypoglycemia has been shown to be extremely high glucose utilisation rate. This does not seem to be the case for the dog (i,i3'i6) or for the cat (17). In these animals hypophysectomy seems to cause an incapacity to free body protein which can supply glucose by glyconeogenesis (1). This is not so for all animals (18). The hypophysectomised rabbit very quickly develops a severe hypoglycemia on fasting (5, 19) and must be given glucose injections in order to prevent death.

Our first work in the study of this problem was to determine the rate at which glucose had to be administered to such animals to keep them out of hypoglycemia.

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