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Endocrinology, doi:10.1210/endo-28-2-214
Endocrinology Vol. 28, No. 2 214-216
Copyright © 1941 by the Endocrine Society.
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GONADOTROPIC AND AUGMENTATIVE EFFECTS OF TESTOSTERONE PROPIONATE IN IMMATURE FEMALE RATS1

C. F. FLUHMANN

From the Department of Obstetrics and Gynecology, Stanford University School of Medicine SAN FRANCISCO, CALIFORNIA

Abstract

ANUMBER of reports from various investigators (1–6) have indicated that testosterone has a gonadotropic effect on the ovaries of immature rats. The object of this communication is to record (a) the effect of increasing doses of testosterone propionate on the weights of the ovaries and uteri of immature female rats, and (b) the results of the preliminary administration of testosterone to animals receiving various gonadotropins.

The rats employed in this study were immature female albinos 21 to 23 days of age at the beginning of each experiment. All were offsprings of the inbred colony which has been maintained at Stanford for many years. The testosterone propionate employed was the preparation manufactured by Ciba under the name of perandren, made up in sesame oil and containing 10 or 25 mg. per cubic centimeter. The gonadotropic hormones were in aqueous solution, and consisted of 2 chorionic gonadotropins, namely follutein.

Footnotes

1 This study was supported in part by the Rockefeller Fluid Research Fund of Stanford University School of Medicine. Due acknowledgment is made to Dr. R. MacBrayer and the Ciba Pharmaceutical Products Inc. for a generous supply of testosterone propionate (perandren); to Dr. H. Jensen and E. R.Squibb & Sons for follutein and FSH powder; to Ayerst, McKenna 6? Harrison for A.P.L.; to Mr. Donald Wonder and the Cutter Laboratories for gonadin. My thanks also are due to Mr. Fred Wong and Mr.Pierre Lassegues for their technical assistance.

Received August 12, 1940.






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Copyright © 1941 by The Endocrine Society