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THYROID-OVARIAN RELATIONS II. THE EFFECT OF CASTRATION AND REPLACEMENT THERAPY ON THYROID, PITUITARY, ADRENAL AND BODY WEIGHT IN THYROHYPER-PLASTIC ALBINO RATS¹

From the Department of Obstetrics and Gynecology, Stanford University School of Medicine SAN FRANCISCO, CALIFORNIA

Abstract

THE MORPHOLOGICAL BEHAVIOR of thyroid glands of rats fed a goiter-producing diet in its relation to the action of ovarian hormones was described in a previous report (1). It was shown that for the duration of feeding neither with-drawal of ovarian hormones nor replacement with ketohydroxyestrin (subsequently referred to here as estrone) influenced thyroid hyperplasia in castrated rats. The administration of progesterone to such rats, however, decreased thyroid hyperplasia materially.

Since in that paper the considerations were purely morphological, the present report furnishes additional information on weight changes in the thyroid, pituitary and adrenal glands, and in the body as a whole.

Seventy 30-day-old thyrohyperplastic female rats of the Wistar strain were divided into 5 groups as shown in table 1. The animals included in 4 of the groups were castrated at this time, the remaining group being reserved for control. At 140

Footnotes

¹ This research was supported in part by the Memorial Fund for Cancer Research and by the Rockefeller Fluid Research Fund of Stanford University.

Received April 8, 1941.

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