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ISLAND HYPERPLASIA IN THE PARTIALLY DEPANCREATIZED RAT

From the Laboratory of Pathology and the George F. Baker Clinic, New England Deaconess Hospital BOSTON, MASSACHUSETTS

Abstract

THE HISTOLOGIC APPEARANCE OF THE ISLANDS OF LANGERHANS in the pancreatic remnants of partially depancreatised animals is the subject of a number of reports. The moststriking change which has been noted is the hydropic de-generation of the beta cells in dogs (1–4). More recently, with reference to rats ren-dered diabetic by subtotal pancreatectomy, Long, Katzin and Fry (5) stated: "The islet tissue of the pancreatic remnants displayed the well-known pathological changes previously described in partially depancreatised dogs. There may be found hyper-trophy and all degrees of islet cell degeneration from the most minor to complete destruction and hyalinization."

It is the purpose of the present report to describe the changes in the pancreas of the partially depancreatized rat in greater detail, and to point out differences between the changes in rats and those observed in dogs.

Footnotes

¹ Littauer Fellow in Pathology.

Received June 26, 1941.

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