help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology, doi:10.1210/endo-29-5-817
Endocrinology Vol. 29, No. 5 817-827
Copyright © 1941 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints, Permissions and Rights
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by TYSLOWITZ, R.
Right arrow Articles by DINGEMANSE, E.
Right arrow Search for Related Content
PubMed
Right arrow Articles by TYSLOWITZ, R.
Right arrow Articles by DINGEMANSE, E.

EFFECT OF LARGE DOSES OF ESTROGENS ON THE BLOOD PICTURE OF DOGS

R. TYSLOWITZ1 and E. DINGEMANSE

From the Pharmaco-therapeutic Laboratory, The University of Amsterdam AMSTERDAM, THE NETHERLANDS

Abstract

ANEMIA IN DOGS CAN BE PRODUCED by the administration of large doses of estrogens, such as estradiol benzoate, estrone (I–6)2 and diethylstilbestrol (7, 8)2 that is by substances ofvaried constitution whose common character-istic is estrogenic activity. Anemia can be produced in both sexes by this means. On the other hand androgenic substances such as testosterone or its propionate do not produce an anemia even after injection for a period of months (6).

Healthy, vigorous dogs were used for the experiments. They were kept on a mixed diet which contained all the known vitamins. Before the investigation was commenced they lived for at least one week in their new surroundings. Blood was taken from the ear of fasting dogs and was analyzed immediately without the addi-tion of anticoagulants. Hemoglobin was measured by Sahli's method and the number of blood corpuscles determined in the Thoma-Zeiss chamber.

Footnotes

1 Present address, Department of Pharmacology, Harvard Medical School, Boston, Massachusetts.

Received August 4, 1941.




This article has been cited by other articles:


Home page
 Arch Intern MedHome page
A. L. Anderson and E. C. Lynch
Myelodyspoietic Syndrome Associated With Diethylstilbestrol Therapy
Arch Intern Med, July 1, 1980; 140(7): 976 - 977.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
B. J. KENNEDY
Stimulation of Erythropoiesis by Androgenic Hormones
Ann Intern Med, December 1, 1962; 57(6): 917 - 936.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
B. A. COOPER and F. S. BIGELOW
THROMBOCYTOPENIA ASSOCIATED WITH THE ADMINISTRATION OF DIETHYLSTILBESTROL IN MAN
Ann Intern Med, April 1, 1960; 52(4): 907 - 909.
[Abstract] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
N. T. SHAHIDI and L. K. DIAMOND
Testosterone-Induced Remission in Aplastic Anemia
Arch Pediatr Adolesc Med, September 1, 1959; 98(3): 293 - 302.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1941 by The Endocrine Society