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Endocrinology, doi:10.1210/endo-30-5-802
Endocrinology Vol. 30, No. 5 802-815
Copyright © 1942 by the Endocrine Society.
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BLOOD LIPIDS OF THE HYPOPHYSECTOMIZEDTHYROIDECTOMIZED DOG1

C. ENTENMAN, I. L. CHAIKOF2 and F.L. REICHERT

The Division of Physiology, University of California Medical School NEW BRUNSWICK, NEW JERSEY The Laboratory of Experimental Surgery, Stanford University School of Medicine SAN FRANCISCO, CALIFORNIA

Abstract

THE THYROID GLAND exerts a definite control over lipid metabolism. The concentration of blood lipids, especially esterified cholesterol and neutral fat, is elevated after thyroidectomy (1). Although the mechanism whereby these changes are produced is still obscure, it has been shown in this laboratory that the thyroidectomised dog differs from the normal in the degree of response of its blood lipids to alterations in nutritional state (2). Wide variations in the dietary regime of the normal dog produce no marked changes in the concentration of blood lipids (3). Thus, acute fasting for as long as 30 days failed to produce much alteration in the levels of total fatty acids, total cholesterol or of phospholipids of the blood in the normal dog. The experimental production of obesity by which normal dogs were made to increase their weights by as much as 50 to 80 per cent in periods as short as 90 days also failed to produce striking changes in the lipid concentration of the blood (4).

Footnotes

1 Aided by grants from the Board of Research, University of California, Berkeley. The assistance furnished by the Works Progress Administration (Official Project No. 65–1–o8–652, Unit A6) is gratefully acknowledged.

2 Fellow of the John Simon Guggenheim Memorial Foundation.

Received April 4, 1942.






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Copyright © 1942 by The Endocrine Society