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INFLUENCE OF SEX ON CARBOHYDRATE METABOLISM

May Institute for Medical Research, The Jewish Hospital, and the Department of Biological Chemistry, University of Cincinnati CINCINNATI, OHIO

Abstract

THAT THERE is a disparity between the liver-glycogen content in the male and female has been known for some time. Thus, Greisheimer (1), studying the effect of various dietary constituents on glycogen formation, found higher concentrations of glycogen in the livers of male rats than in those of females, particularly after the feeding of lard and of glycerol. Likewise, Stohr (2) reported that, with the exception of very old animals, the livers of males consistently maintained a higher level of glycogen after various periods of fasting. Similar differences were observed by Sjogren (3) during the course of an investigation of the diurnal variations in the glycogen content of the livers of male and female rabbits.

More recently, Deuel, Gulick, Grunewald and Cutler (4) administered measured amounts of glucose by stomach tube to male and female rats and determined the liver-glycogen content after fasting the animals for o, 24, 48 and 72 hours.

Footnotes

¹ Submitted for partial fulfillment for requirements for degree of Doctor of Philosophy, Department of Biological Chemistry, University of Cincinnati.

Received July 11, 1942.