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ANTIHORMONE FORMATION FOLLOWING THE ADMINISTRATION OF GONADOTROPHIC EXTRACTS

IT IS WELL KNOWN that antigonadotrophins form in the blood of experimental animals following the administration of pregnant mare serum. Furthermore antagonists to pregnant mare serum develop in the human and consequently present a complicated factor in the clinical use of this hormone (Rowlands and Spence, 1939; Jailer and Leathern, 1940; Leathern and Abarbanel, 1943). Recently another preparation involving a combination of sheep anterior pituitary extract and human chorionic gonadotrophin (Synapoidin) has been made available for clinical use. Mazer and Ravetz (1941) reported ovarian stimulation in 20 of 23 patients treated with this combination of gonadotrophins and since that time various clinical results have been obtained. Limited tests for the presence of antigonadotrophins in the sera of patients following treatment with this extract have yielded negative results (Jailer and Leathern, 1940; Leathern and Abarbanel). On the other hand, allergic manifestations have been noted in patients treated with Synapoidin (Phillips, 1942; Davis, Madden and Hamblen, 1943) but this does not preclude the formation of antigonadotrophins.

Received September 25, 1944.