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THE EFFECT, IN RATS, OF HIGH FAT DIETS ON THE RENAL EXCRETION OF WATER AND ANTIDIURETIC SUBSTANCES

From the Department of Medicine NEW YORK UNIVERSITY COLLEGE OF MEDICINE

This Research was aided by grants from The Nutrition Foundation and The Ledcrle Laboratories....

Abstract

IT HAS BEEN repeatedly observed that a high fat, low protein diet will cause fatty infiltration of the liver in rats and, if continued for a long enough period of time, will result in a disease of the liver consisting of portal cirrhosis with occasional necrosis (Gyorgy 1944, Webster 1941, Gyorgy and Goldblatt 1941). Shay, Kolm, and Fels (1945) reported that when rats fed this diet were subjected to water tolerance tests, they excreted less of the administered water than rats fed a normal diet. These investigators did the tolerance tests after the animals had been on the diets for periods up to eighteen days. The physiological state of the kidney was measured by the excretion of phenol red in the urine after it had been injected intraperitoneally. The diet did not impair the ability of the kidneys to excrete phenol red, although a definite depression in water excretion was observed very early in the course of the diet.

Received April 21, 1947.