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THE EFFECT OF INANITION ON THE ANTERIOR PITUITARY-ADRENOCORTICAL INTERRELATIONSHIP IN THE GUINEA PIG¹

From the Department of Biology, Washington Square College of Arts and Science, New York University NEW YORK, NEW YORK

Abstract

IT IS ABUNDANTLY clear from both clinical studies and those on laboratory animals that malnutrition profoundly modifies the structure and function of endocrine glands, and that these modifications eventuate in hypofunction of the entire endocrine system (Jackson, 1925, 1929, Stephens, 1941). Convincing experimental evidence has been presented, moreover, which indicates that the regressive changes appearing in various target organs, for example, gonad and thyroid, are attributable largely to suppression of appropriate trophic mechanisms in the pituitary of the starved animal (Mason and Wolfe, 1930; Selye and Collip, 1936; Werner, 1939; Mulinos and Pomeranz, 1940; Stephens, 1940; and D’Angelo, Gordon, and Charipper, 1942). A striking and exceptional change in this general pluriglandular deficiency is the hypertrophy of the adrenal cortex which occurs in certain starvation states. Themany circumstances in which the adrenals are known to hypertrophy have been collated byTepperman, Engel, and Long (1943a);

Footnotes

¹ We are indebted to Dr. Malvina Schweizer for performing the operations.

Received March 15, 1948.

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