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Endocrinology, doi:10.1210/endo-47-4-251
Endocrinology Vol. 47, No. 4 251-259
Copyright © 1950 by the Endocrine Society.
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THE INFLUENCE OF THIOCARBONAMIDES AND CERTAIN OTHER SULFUR COMPOUNDS ON ALLOXAN DIABETES IN RATS1

I. N. ROSENBERG2 and M. S. RABEN3

From the Joseph H. Pratt Diagnostic Hospital and the Department of Medicine, Tufts College Medical School Boston, Massachusetts

Abstract

SINCE it has been known that insulin has a high cystine content and that the integrity of the disulfide linkage is essential for its physiological action, the relationship of sulfhydryl-disulfide systems to carbohydrate metabolism and diabetes mellitus has been the subject of speculation. Interest in this problem increased when it was reported that alloxan diabetes in rats could be prevented by the injection of large amounts of glutathione or cysteine intravenously very shortly prior to the intravenous administration of ordinarily diabetogenic doses of alloxan (Lazarow, 1946a). 2, 3-dimercaptopropanol (BAL) orally or parenterally also protected rats against alloxan (Chesler and Tislow, 1947). More recently, Houssay and his associates observed that the oral administration to rats of cysteine, thiouracil, and 5-methylthiouracil for twelve to thirty days also protected them from the effects of alloxan subsequently injected (1948a), and prevented the onset of diabetes in a significant proportion of partially depancreatized animals (1948b); thiourea, uracil, uramil, nucleotides, and sulfanilamide were ineffective in preventing the alloxan action.

Footnotes

1 Aided in part by grants from the Committee on Endocrinology of the National Research Council and the American Cyanamid Company, Stamford, Connecticut.

2 U. S. Public Health Service Postdoctoral Research Fellow.

3 AEC Postdoctoral Research Fellow in the Medical Sciences of the National Research Council.

Received May 29, 1950.






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Copyright © 1950 by The Endocrine Society