This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints, Permissions and Rights Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by HAYES, M. A. Articles by BAKER, B. L. Search for Related Content PubMed PubMed Citation Articles by HAYES, M. A. Articles by BAKER, B. L.

THE EFFECT OF PARENTERALLY ADMINISTERED AD-RENOCORTICAL EXTRACT ON THE INTRADERMAL SPREADING ACTION OF HYALURONIDASE¹,^,2

From the Departments of Surgery and Anatomy, University of Michigan Medical School Ann Arbor, Michigan

Abstract

HAYES, Reed and Baker (1950) reported that prolonged direct application of an alcoholic adrenocortical extract to the skin of rats caused a marked acceleration in the spreading action of hyaluronidase, this effect being evident chiefly in the area of treatment. The concept that adrenal steroids promote hyaluronidase activity stands in contrast to the impressive array of data compiled by other investigators which demonstrate that adrenocortical extract (Opsahl, 1949 a, b, c; Winter and Flataker, 1950; Seifter, Baeder and Begany, 1949), cortisone (Winter and Flataker, 1950; Seifter et al., 1950; Seifter, Baeder and Dervinis, 1949; Opsahl, 1949a) and ACTH (Seifter et al., 1950) decrease the activity of hyaluronidase. There seemed to be at least two possible explanations for the contradictory findings of Hayes, Reed and Baker (1950). First, the acceleration of spreading action as revealed by prolonged local application of adrenal steroids might be an outcome of the local application technique.

Footnotes

¹ Supported by The Lawrence J. Montgomery Research Fund and grants from G. D. Searle and Company, from The Upjohn Company and from the Division of Research Grants and Fellowships, United States Public Health Service (C-767-(c)).

² The technical assistance of Mrs. A. D. Bridgeman is gratefully acknowledged.

Received May 14, 1951.

This article has been cited by other articles:

				W. D. ROBINSON, J. J. BUNIM, W. S. CLARK, D. C. CRAIN, E. P. ENGLEMAN, D. C. GRAHAM, M. M. MONTGOMERY, B. M. NORCROSS, C. RAGAN, M. W. ROPES, et al. RHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS * (ELEVENTH RHEUMATISM REVIEW) * Part II Ann Intern Med, December 1, 1956; 45(6): 1059 - 1210. [Abstract] [PDF]