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Endocrinology, doi:10.1210/endo-50-5-574
Endocrinology Vol. 50, No. 5 574-579
Copyright © 1952 by the Endocrine Society.
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PHYSIOLOGICAL INTERACTION OF CORTISONE ACETATE AND DIETHYLSTILBESTROL. LACK OF ANDROGENIC OR ESTROGENIC EFFECTS OF CORTISONE ACETATE1

PAUL TALALAY2, MARIE MOLLOMO, CARL M. EBERSOLE and CHARLES HUGGINS

From the Ben May Laboratory for Cancer Research, University of Chicago Chicago, Illinois

Abstract

IT HAS been shown that appreciable regression of human prostatic and mammary neoplasms occurs in some cases after bilateral adrenalectomy (Huggins and Bergenstal, 1951; 1952) with the use of cortisone acetate as maintenance substitution therapy. Since these tumors are neoplasms which are known to be influenced by sex hormones, it became important to know whether cortisone acetate had androgenic or estrogenic effects and if this compound could modify significantly the physiologic action of sex hormones on the accessory sex structures. These experiments will demonstrate that cortisone acetate does not stimulate the canine prostate nor the uterus of the rat but inhibits partially the action of diethylstilbestrol on the uterus.

Kochakian (1944) found that the implantation of a pellet of cortisone in castrate male mice did not cause growth of the accessory reproductive structures. The administration of cortisone acetate to intact male rats did not greatly modify the histological

Footnotes

1 This study was aided by grants from the Jane Coffin Childs Memorial Fund for Medical Research and from the American Cancer Society recommended by the Committee on Growth of the National Research Council.

2 Senior Assistant Surgeon, Federal Security Agency, United States Public Health Service.

Received December 22, 1951.






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Copyright © 1952 by The Endocrine Society