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THE SIMILARITY BETWEEN ANEMIA INDUCED BY HYPOPHYSECTOMY AND THAT INDUCED BY A COMBINED THYROIDECTOMY AND ADRENALECTOMY IN ADULT FEMALE RATS¹

The Department of Anatomy, University of Cincinnati College of Medicine Cincinnati, Ohio

Abstract

THE mechanism by which removal of the hypophysis induces an anemia (see reviews by Gordon and Charipper, 1947, and Daughaday, Williams and Daland, 1948) is still unsolved. Thyroidectomy in rats has been shown to induce an anemia which was not as severe as that induced by hypophysectomy (Crafts, 1941; Wilson, 1944; Gordon, Kadow, Finkelstein and Charipper, 1946). Adrenalectomy in rats has been shown to induce an anemia 10 to 20 days after removal of the glands. This anemia, however, gradually disappeared. Sixty days after adrenalectomy, the blood picture was normal (Crafts, 1941; Piliero, Landau and Gordon, 1950; Gordon, Piliero and Landau, 1951).

Many different therapies have been utilized in an attempt to prevent the anemia which develops following hypophysectomy. Those which have been completely effective are pituitary extracts (Flaks, Himmel and Zlotnik, 1938; Contopoulos, Van Dyke, Simpson, Garcia, Huff, Williams and Evans 1953), a combination of thyroxine, testosterone propionate, and a high protein diet (Crafts, 1949), and cobalt nitrate (Crafts, 1952; Garcia, Van Dyke and Berlin, 1952).

Footnotes

¹ Supported by a contract between the University of Cincinnati and the Office of Naval Research, Washington, D. C.

² With the technical assistance of Dorothy J. Turnbull and Nancy H. Lancaster.

Received March 9, 1953.