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THE EFFECTS OF LOW PRESSURE ON HEMOPOIESIS IN THE ADRENALECTOMIZED RAT¹

Department of Anatomy, New York Medical College, Flower and Fifth Avenue Hospitals New York, New York

Abstract

IN VIEW of the steadily increasing emphasis being placed on the adrenal gland as a regulator of many phases of body metabolism, a detailed correlation of the peripheral blood changes to the bone marrow cytology in the adrenal insufficient animal, with and without replacement therapy, was made in an effort to determine the mechanisms underlying the influence of adrenal cortical principles upon the blood elements (Gordon and Piliero, 1950; Piliero, Landau and Gordon, 1950; Gordon, Piliero and Landau, 1951).

A more sensitive technique has been utilized for determining a possible relation of the adrenal to hemopoiesis through subjecting adrenalectomized and sham operated controls to an erythropoietic stress, namely lowered barometric pressures. The results of one phase of this study will be described in the present paper.

MATERIALS AND METHODS

Young adult female rats of a hardy, closely inbred strain and weighing 160–200 gm. were employed.

Footnotes

¹ Supported in part by Grant RG-4032 (C), Public Health Service and contract AF 18 (600)-1255, U. S. Air Force School of Aviation Medicine, Randolph Field, Texas.

Received June 21, 1955.