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During the winter and spring a considerable number of mature estrogen-treated female rabbits ovulated in the absence of coital stimulation. Such spontaneous ovulation following estrogen administration was not observed during the summer and early autumn months.
Footnotes
1 Supported in part by a grant (B1162) from the National Institutes of Health. The work was started at Duke University, Durham, North Carolina, and completed in California. It was written while the author was a Fellow of the Commonwealth Fund, 1958–59.
Received April 27, 1959.
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