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Participation of Parathyroid Glands in Control of Calcium Absorption in Dogs

Department of Physiology, University of British Columbia Vancouver, B.C., Canada

This research was supported by Grant MT-774 from the Division of Medical Research of the National Research Council of Canada.

Abstract

A study was made of the effect of thyroparathyroidectomy and of the administration of parathyroid extract on the rate of calcium absorption from healed Thiry- Vella jejunal fistulas in 12 dogs.

Parathyroidectomy resulted in a significant reduction in the calcium absorption rate to 70% of the control value after 24 or more hours.

The administration of parathyroid extract to parathyroidectomized dogs restored calcium absorption to normal by 24 hr. The administration of parathyroid extract to normal dogs also increased the calcium absorption rate significantly. This effect lasted only 48 hr. These observations may explain in part the adaptation of calcium absorption which has been reported in animals on a low calcium diet.

Received April 28, 1962.