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Effects of Thyropropionic Acid and 3,3',5-Triiodothyropropionic Acid on Oxygen Consumption, Goiter Prevention and Cholesterol Biosynthesis in the Rat¹

Department of Biochemistry and Department of Physiology, Warner Lambert Research Institute Morris Plains, New Jersey

Abstract

Thyropropionic acid (T₀P) had no perceptible calorigenic or goiter prevention effects in rats. T₀P at 400 mg/100 g in the rat diet for 2 weeks caused no significant change in serum or liver cholesterol from controls, but it did cause a 51 % inhibition of intraperitoneally injected acetate-l-C¹⁴ incorporation into liver cholesterol. In contrast, T₃P in the rat diet in dilutions as low as 0.20 mg/100 g for 2 weeks, while elevating oxygen consumption only slightly above controls, produced a significant 27.2% lowering in serum cholesterol and inhibited incorporation of acetate-1-C¹⁴ into liver cholesterol 36.6%. T₃P, like T₀P, did not lower liver cholesterol content in this short time. T₃P may play a multiple role in its effects on cholesterol metabolism in vivo.

Footnotes

¹ Preliminary results pertaining to this study appeared in abstract form [Circulation XXIV (part 2): 1090, 1961].

Received May 24, 1962.