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Endocrinology, doi:10.1210/endo-74-4-518
Endocrinology Vol. 74, No. 4 518-520
Copyright © 1964 by the Endocrine Society.
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Effect of Insulin on Glutamine Synthetase Activity in Rat Liver

A.L. KENNAN

Department of Gynecology and Obstetrics, University of Wisconsin School of Medicine Madison, Wisconsin

Supported in part by a grant (#AM-3313) from the USPHS.

Abstract

It has been demonstrated previously that glutamine synthesis is defective in alloxan-diabetic rats. Forty-eight hr after paired rats were given alloxan, one was given insulin and one saline intravenously, to ascertain the effect of insulin on glutamine synthetase activity. Tests were conducted at 2-, 4- and 6-hr intervals after the insulin injection. The animals given insulin showed a definite increase in activity compared to the controls. (Endocrinology 74: 518, 1964)

Received July 31, 1963.






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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
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Copyright © 1964 by The Endocrine Society