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Endocrinology, doi:10.1210/endo-80-5-931
Endocrinology Vol. 80, No. 5 931-937
Copyright © 1967 by the Endocrine Society.
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Acid Mucopolysaccharide Alterations in Experimental Exophthalmos1

JAMES C. SISSON and MARJORIE MILES

Nuclear Medicine Unit, Department of Internal Medicine, University of Michigan Medical Center Ann Arbor, Michigan 48104

Supported by Grant AM-08495-03 from the USPHS National Institute of Arthritis and Metabolic Diseases.

Abstract

Injections of thyrotropin in guinea pigs induced an experimental exophthalmos which was associated with increased concentrations of acid mucopolysaccharides in the retrobulbar tissues. Hyaluronic acid (HA) was the acid mucopolysaccharide component affected, and the response to thyrotropin in thyroidectomized animals was log-dose in form. There was a lesser increment in tissue HA with a more purified thyrotropin when related to the thyroid stimulating effect. Other anterior pituitary hormones were without effect. Thyroxine produced a decrease in the hyaluronic acid concentrations of all tissues examined. It was in the most internal structures of the guinea pig orbit, i.e., harderian gland and extraocular muscles, that the acid mucopolysaccharide metabolism was responsive to thyrotropin. Although this effect appeared by histochemical methods to be localized to the connective tissue elements of these structures, other tissues (eyelids and skin) with abundant connective tissue had no augmentation of HA by thyrotropin. (Endocrinology 80: 931, 1967)

Footnotes

1 Presented in part at the American Endocrine Society Meeting, Chicago, 111., June 1966.

Received October 27, 1966.




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Copyright © 1967 by The Endocrine Society