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Endocrinology, doi:10.1210/endo-82-1-132
Endocrinology Vol. 82, No. 1 132-136
Copyright © 1968 by the Endocrine Society.
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Evidence for the Secretion of Thyrocalcitonin at Normal and Subnormal Plasma Calcium Levels

D. C. KLEIN1 and ROY V. TALMAGE

Rice University Houston, Texas 77001

Abstract

The role of the thyroid in response to calcium challenge was examined. A continuous calcium load of 2 mg/hr for 4 hr was delivered by peritoneal lavage using a 12.0–12.5 mg/100 ml calcium lavage rinse in rats made hypocalcemic by prior thyroparathyroidectomy and/or parathyroidectomy. The bones of these animals had been labeled 1–2 weeks earlier with appropriate radioisotopes (86Sr, 45Ca). Although only slight differences in both plasma calcium and total transfer of calcium out of lavage fluid could be observed between the 2 groups, a marked difference developed in the amount of radioisotopetransferred to lavage fluid. After 3–4 hr, animals with functional thyroids transferred 25% less radioactivity into the lavage fluid than animals without these glands. Control studies indicated that thyroxine was not responsible for this particular effect. This evidence has been interpreted as a demonstration that thyrocalcitonin secretion had been elicited by the calcium challenge. In addition, because plasma calcium levels were never elevated above normal, the data also suggested that thyrocalcitonin was secreted and effective in rats at normal and subnormal plasma calcium levels. (Endocrinology 82: 132,1968)

Footnotes

Aided in part by grants from A.E.C. and N.I.D.R.

1 Present address: Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, N. Y.

Received July 10, 1967.






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Copyright © 1968 by The Endocrine Society