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Histamine Concentrations in Normal and Cystic Rat Ovaries

Bureau of Biological Research, Rutgers, The State University New Brunswick, New Jersey 08903

This investigation was supported in part by Research Grants A-2321 from the Institute of Arthritis and Metabolic Diseases and by GM-835 from the Institute of General Medical Sciences of the NIH, USPHS.

Abstract

Total ovarian free histamine was reduced by feeding 0.5% thiouracil for 30 days and more acutely by administration of human chorionic gonadotrophin (HCG) for 20 days. Histamine levels were still further depressedwhen hypothyroid animals were given HCG for 5 and 10 days but not when treatment was extended to 15 to 20 days. Histamine release may be associated with the subsequent development of cystic follicles. (Endocrinology 82: 171, 1968)

Footnotes

¹ Present address: Department of Biology, Brown University, Providence, R. I.

² Human chorionic gonadotrophin (Follutein) was generously supplied by E. R. Squibb & Sons.

Received July 28, 1966.

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