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Effects of Adrenalectomy and Manner of Food Intake on Renal Gluconeogenesis

Pediatric Research Laboratories, Department of Pediatrics and Division of Nutritional Sciences Chicago, Illinois 60616
Department of Medicine, Michael Reese Hospital and Medical Center Chicago, Illinois 60616

This work was supported in part by USPHS Grants AM-00193 and AM-08591 and by Grant GB-5840 from the National Science Foundation.

Abstract

When both the prior quantity and timing of food ingestion by normal and adrenalectomized rats was controlled, there was no difference in the rates of in vitro gluconeogenesis by the kidneys of the 2 groups of animals. An increase in the quantity of food ingested by normal animals, eating under ad lib. conditions, was associated with increased carbohydrate formation by their kidneys, when compared to those of rats lacking adrenals and eating in a similar manner. With pair feeding conditions, kidneys of normal rats that had consumed a limited amount of food in a short time period likewise demonstrated increased gluconeogenesis. Cognizance must be taken of dietary habits when attempting to evaluate hormonal influences on intermediary metabolism. (Endocrinology 84: 417, 1969)

Received June 23, 1967.