This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints, Permissions and Rights Citing Articles Citing Articles via Google Scholar Google Scholar Articles by AVERILL, R. L. W. Articles by NEWMAN, W. C. Search for Related Content PubMed PubMed Citation Articles by AVERILL, R. L. W. Articles by NEWMAN, W. C.

Biliary Secretion of Thyroxine in Rats with Thyroid-Depressing Hypothalamic Lesions

Department of Physiology, University of Tennessee Memphis, Tennessee 38103

This work was supported by USPHS Grant AM 11379 and USPHS Grant CA 10323.

Abstract

The ¹³¹I-labeled thyroxine (¹³¹I-T₄) clearance and biliary secretion was studied in rats with confirmed depression of thyroid function following hypothalamic lesions. Biliary secretion and clearance of ¹³¹I-T₄ over a 4-hr period were both significantly lower in rats with lesions than in controls, but the total volume of bile did not differ between groups. Plasma ¹³¹I-T₄ levels were higher in the lesioned rats than in controls 3 1/2 hr after injection of labeled T₄. (Endocrinology 84: 950, 1969)

Footnotes

¹ Present address: Department of Physiology, Tulane University School of Medicine, New Orleans, La.

Received September 6, 1968.