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Endocrinology, doi:10.1210/endo-86-6-1436
Endocrinology Vol. 86, No. 6 1436-1440
Copyright © 1970 by the Endocrine Society.
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Prostaglandins: Stimulation of Bone Resorption in Tissue Culture

DAVID C. KLEIN1 and LAWRENCE G. RAISZ

Departments of Pharmacology and Toxicology and of Medicine, University of Rochester School of Medicine and Dentistry Rochester, New York 14620

Abstract

Prostaglandins (PG’s) stimulated resorption of fetal rat bone in 48–96 hr tissue culture. The effects of several PG’s were compared to the stimulation of bone resorption caused by parathyroid hormone (PTH). PGE1 and PGE2 caused increased release of previously incorporated radioactive calcium into the medium, losses of stable and labeled Ca from the bone and morphologic changes of osteoclastic resorption at 10–5-10–8M. The effects of PGE1 and PGE2 were similar to those of PTH (10–7- 10–8M) but in some experiments the effects of maximal doses of PTH were larger at 48 hr. Like PTH, the effects of PGE1 were inhibited by thyrocalcitonin and cortisol. PGA1 and PGFl{alpha} also stimulated bone resorption but only at higher doses (10–5M). In vivo studies demonstrated that injections of PGE1 in parathyroidectomized rats did not increase serum calcium concentration, while parathyroid extract (4–40 U/rat) was effective. (Endocrinology 86: 1436, 1970)

Footnotes

Supported by Grants AM 06205 and GM 15190.

1 Present address: Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, Bldg. 125, Room 35, National Naval Medical Center, Bethesda, Md. 20014.

Received January 8, 1970.




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