This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints, Permissions and Rights Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by HENDRICKS, S. E. Articles by GERALL, A. A. Search for Related Content PubMed PubMed Citation Articles by HENDRICKS, S. E. Articles by GERALL, A. A.

Effect of Neonatally Administered Estrogen on Development of Male and Female Rats

Department of Psychology, Tulane University New Orleans, Louisiana 70118

Abstract

This investigation is, in part, a replication of a study which reported that neonatally administered estrogen masculinizes the genetic female rat to the extent that it exhibits ejaculatory responses. Male and female rats were injected when 4 days old with either 100 µg estradiol benzoate (EB) or oil. In comparison to controls, males neonatally injected with EB had delayed testicular descent and decreased male sexual behavior, body weight and testis weight. Upon histological examination, the testes of EB-treated males were found to have tubular abnormalities. While females injected neonatally with EB exhibited more incomplete and completecopulatory responses to exogenous androgen given at maturity than control subjects, none exhibited ejaculatory patterns. EBtreated females had precocious vaginal openings, disrupted vaginal cycles, anovulatory ovaries and heavier than normal postpuberal body weights.(Endocrinology 87:435,1970

Footnotes

¹ Present-address: Department of Psychology, University of Nebraska at Omaha, Omaha, Neb.68101.

Received January 14, 1970.

This article has been cited by other articles:

				Y. Shi and E. H. Schlenker Neonatal sex steroids affect ventilatory responses to aspartic acid and NMDA receptor subunit 1 in rats J Appl Physiol, June 1, 2002; 92(6): 2457 - 2466. [Abstract] [Full Text] [PDF]