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ANSK
1ILaboratory of Clinical Science, National Institute of Mental Health Bethesda, Maryland 20014
Supported in part by The Scottish Rite Committee on Research in Schizophrenia, The National Association for Mental Health, Inc.
Abstract
Repeated daily immobilizationof rats results in a neuronally dependent elevation of tyrosine hydroxylase in the adrenal medulla. Phenylethanolamine-N-methyl transfera selevels are also increased. After cessation of immobilization intervals, tyrosine hydroxylaselevels decrease toward preimmobilization levels with a half-life of about 3 days. These results are discussed with reference to the changes in adrenal and urinary catecholamine levels found with repeated stress and estimation of the rate of tyrosine hydroxylase synthesis. (Endocrinology 87: 744, 1970)
Footnotes
1 Fellow, Foundations' Fund for Researc in Psychiatry, Research Grant NG 68-415. Slovak Academy of Sciences, Institute of Experimental Endocrinology, Bratislava, Czechoslovakia.
Received February 17, 1970.
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