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Thyroid Secretion in Vitro: Inhibition of TSH and Dibutyryl Cyclic-AMP Stimulated ¹³¹I Release by Li⁺¹

National Institute of Arthritis and Metabolic Diseases and National Institute of Mental Health Bethesda, Maryland 20014

Abstract

The effect of various Li⁺ treatments on the release of ¹³¹I in vitro by mouse thyroid glands was studied. Chronic Li⁺ feeding and acute Li⁺ injection inhibited both DBCAMP- stimulated release of ¹³¹I and TSH-stimulated release of ¹³¹I. By use of preincubation with Li⁺, inhibition of TSH-stimulated ¹³¹I release was demonstrated in a completely in vitro system. ¹³¹I release and colloid droplets were decreased in parallel. Li⁺ inhibition of thyroid secretion thus occurs at a step between the generation of intracellular cyclic-AMP and colloid droplet formation. (Endocrinology 88:1385,1971)

Footnotes

¹ A preliminary report has been published (J Clin Invest 41: 9a, 1970).

Received December 8, 1970.

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