This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints, Permissions and Rights Citing Articles Citing Articles via Google Scholar Google Scholar Articles by JARABAK, J. Articles by STREET, M. A. Search for Related Content PubMed PubMed Citation Articles by JARABAK, J. Articles by STREET, M. A.

The Inhibition of the Soluble Human Placental 17β-Hydroxysteroid Dehydrogenase by o,p'-DDD¹ and Its Analogs

The Fisher Endocrine Laboratories, Department of Medicine, Pritzker School of Medicine, University of Chicago Chicago, Ill. 60637

Abstract

o,p'-DDD is a more potent inhibitor of the human placental 17β-hydroxysteroid dehydrogenase than any of the structural analogs, non-steroidal estrogens or anti-estrogens that have been examined. This inhibition is competitive with respect to 17β-estradiol. Both o,p'-DDD and diethylstilbesterol compete for the same binding site. (Endocrinology 89: 1407, 1971)

Footnotes

¹ The abbreviations used are: o,p'-DDD, 2-(2-chlorophenyl)-2-(4-chlorophenyl)-l, 1-dichloroethane; m,p'-DDD, 2-(3-chlorophenyl)-2-(4-chlorophenyl)-1, 1-dichloroethane; p,p'-DDD, 2,2-bis(4-chlorophenyl)-l,l-dichloroethane; o,p'-DDT, 2-(2-chlorophenyl)-2-(4-chlorophenyl)-l, 1,1-trichloroethane, p,p'-DDT, 2,2-bis(4-chlorophenyl)- l,l,l-trichloroethane; p,p'-DDE, 2-(2-chlorophenyl)-2-(4-chlorophenyl)-l, 1-dichloroethylene; U-11,100A,l-(2-[p-(3)4-dihydro-6-methoxy-2-phenyl-1-naphthyl) phenoxy] ethyl) pyrrolidine hydrochloride; CI-628, l-[2-(p-[-(p-methoxyphenyl)-βnitrostyryl] phenoxy) ethyl] pyrrolidine monocitrate.

Received May 7, 1971.