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A Study of the Stability of Calcitonin Biological Activity¹

Department of Physiology, University of British Columbia Vancouver, B.C.

Abstract

Preparations of calcitonin from six vertebrate species (man, hog, cow, salmon, cod, chicken) were all shown to be hypocalcemic in young rats. Doses of non—mammalian calcitonins produced longer lasting hypocalcemia than equivalent doses (as determined in the bioassay) of mammalian calcitonin. The hypocalcemic activity of the non—mammalian calcitonins was more persistent than that of their mammalian counterparts during in vitro incubation in rat plasma. The rate of hormone activity loss from the plasma of rats during in vivo tests was more rapid than in the in vitro tests. Non—mammalian calcitonin activity lasted longer than that of mammalian hormones. This relationship was preserved in the nephrectomized rat. (Endocrinology 92: 1102, 1973)

Footnotes

¹ Supported by Grants from the Medical Research Council of Canada and the British Columbia Medical Research Foundation.

² Medical Research Council of Canada Studentship holder. Current address: Department of Zoology, Cambridge University, Cambridge, England

³ Reprint requests to C. 0. P.

Received May 25, 1971.

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