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Rabbit Testosterone-Binding Globulin. II. Effect on Androgen Metabolism In Vivo

Centre de Recherches Endocrinologigues, HÚpital Cochin, Paris France, and U 36 Research Unit, Paris, France

Abstract

Sexually mature Fauve de Bourgogne rabbits were investigated to determine the role of Testosterone—Binding—Globulin (R—TeBG) on androgen metabolism. The binding capacity of R—TeBG, determined by polyacrylamide gel electrophoresis, was elevated, and not significantly different in 9 males (3.46 ± 1.22 (SD) µg steroid bound/100 ml) and in 7 females (4.85 ± 2.53). The metabolic clearance rate of testosterone (MCR^T) was similar in 6 males (1.63 ± 0.27 (SD) liter/Kg/hr) and 4 females (1.96 d= 0.73). The MCR of androstenedione was 4 times higher than MCR^T in both sexes. The MCR of dihydrotestosterone in 2 males and 2 females was equal to MCR^T. Plasma concentration and blood production rate of testosterone were: 549 ± 384 (SD) ng/100 ml and 9.62 ± 7.62 M-g/kg/hr, respectively, in males; 22.5 ± 7.1 and 0.48 ± 0.29 in females. A significant correlation (p < 0.05) was found between unbound plasma testosterone and MCR^T in males, but not in females. It is concluded that MCR^T depends mainly upon specific binding to R—TeBG, but does not reflect the sexual differences in tissue extraction of the androgen. (Endocrinology 92: 1120, 1973

Received August 28, 1972.

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