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Enzymatic Oxidation and Reduction of C₁₉–⁵–3β–Hydroxysteroids by Hepatic Microsomes. II. Effect of Age in Rats on 16,17–Oxido—Reduction of 3β–Hydroxyandrost–5–en–17–one (DHA)¹

Department of Obstetrics and Gynecology, University of Washington School of Medicine Seattle, Washington 98195

Abstract

The activities of the DHA 16hydroxylase, and the 16– and 17β–hydroxysteroid dehydrogenases of hepatic microsomes of male and female rats have been studied in animals from 20 to 105 days of age. These C–16–oxidoreductases are sex—linked with a significant accumulation of their products, 16–keto—A5–diol, 16–0H—DHA and A5–triol appearing in males at puberty and increasing thereafter. The formation of 16–keto—A⁵–diol predominated over that of 16– OH—DHA at all ages. In contrast, the formation of A⁵–diol, reflecting the DHA–17β–hydroxysteroid dehydrogenase activity was neither sex—linked nor increased after puberty in either sex. (Endocrinology 92: 1161, 1973)

Footnotes

¹ Portions of this work have been reported at the 53rd Annual Meeting of The Endocrine Society, San Francisco, 1971, Abstract No. 207.

Received October 2, 1972.