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Fluctuations in Plasma Testosterone Levels in Adult Male Rats and Mice

Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545, and Department of Obstetrics and Gynecology, Yale University School of Medicine New Haven, Connecticut 06510

Abstract

Testosterone (T) levels in the plasma of male laboratory rats and mice were measured by radioimmunoassay. There was a striking individual variation with values ranging from less than 1 ng/ml to over 30 ng/ml in mice of the same age and strain housed under identical conditions. Using chronic indwelling catheters inserted into a jugular vein, blood was collected from adult conscious male rats every 24 hr for 4 or 8 days and every 30 min for 2l/2 or 8 hr. Considerable differences in plasma T levels were observed between different animals, and 2– to 5–fold fluctuations of T concentrations in the plasma were detected between samples collected from the same animal at different times. These large and irregular changes in plasma levels of T are unlike the fairly stable levels observed in the human but bear certain resemblance to the pulsatile release of T described in bulls and rams and perhaps also to the social dominance related differences in plasma T levels in Rhesus monkeys. (Endocrinology 92: 1223, 1973)

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