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Effect of Polyphloretin Phosphate on the Induction of Thyroid Hormone Secretion by Various Thyroid Stimulators

Department of Pharmacology and Histology, University of Lund, Lund, Sweden; and the Endocrinology and Metabolism Section, Veterans Administration Hospital and the Department of Medicine, University of California San Francisco, California

Abstract

The influence of polyphloretin phosphate (PPP), a presumed antagonist of prostaglandin, on the secretion of thyroid hormone was studied in ¹³¹I—injected, T₄–suppressed mice treated with various thyroid—stimulating substances. Indices of response were the formation of colloid droplets and the increase in blood radioiodine (BRI) levels. Administration of PPP 5 min prior to thyrotrophin (TSH) or the long—acting thyroid stimulator (LATS) reduced both the colloid droplet formation and the BRI increments induced by these stimulators. On the other hand, the responses to prostaglandin E₁; norepinephrine, 5–hydroxytryptamine, isoproterenol, and dibutyryl—cyclic adenosine–3'5'—monophosphate were either unimpaired or augmented by PPP. It is suggested that PPP selectively inhibits TSH— and LATS—stimulated secretion of thyroid hormone, by an action on specific receptor sites. (Endocrinology 92: 1269, 1973)

Received August 17, 1972.