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Suppression of Aldosterone in Salt—Susceptible and Salt—Resistant Rats¹

Penrose Research Laboratory, Philadelphia Zoological Society, Philadelphia, Pennsylvania 19104, The Department of Pathology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, and Medical Department, Brookhaven National Laboratory Upton, New York 11973

Abstract

Aldosterone production and zona glomerulosa size were studied in relation to salt intake in rats which were selectively bred for susceptibility (S) or resistance (R) to the hypertensive effect of high salt diet. With both in vitro or in vivo systems S rats suppressed aldosterone production In response to salt as much or more than Z animals. Zona glomerulosa mass was not different between S and R rats on various salt intakes. It is concluded that S rats are able to normally suppress aldosterone in response to salt in spite of their genetically controlled increment in adrenal 18–hydroxylase activity reported previously. (Endocrinology 92: 1286, 1973)

Footnotes

¹ Dr. Rapp is supported by research Grants from the U.S. Public Health Service (USPHS; HL–11293), The American Heart Association (71–661) and a Research Career Development Award (USPHS AM– 10543). Dr. Dahl is supported primarily by the US Atomic Energy Commission with partial support from The American Heart Association (70–722) and the USPHS (HL–13408 and HL–14913).

Received August 15, 1972.

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