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Effect of Estradiol Benzoate on the Degradation of Insoluble Collagen of Rat Skin¹

Department of Medicine, The Pritzker School of Medicine, University of Chicago, and the Argonne Cancer Research Hospital Chicago, Illinois 60637

Abstract

Young female rats were injected with ¹⁴C-proline which was incorporated into collagen and converted, in part, to ¹⁴C-hydroxyproline (hypro).⁴ After 2—5 weeks (to allow the bulk of the radioactivity in collagen to be converted to insoluble collagen), we divided the animals into 2 groups. One group was given 50 µg of estradiol benzoate 3 times weekly, while the other served as control. Skin samples obtained by serial biopsy were analyzed for collagen content and ¹⁴C-hypro. Estrogen treatment resulted in prolongation of the half-life of collagen ¹⁴C-hypro to values averaging greater than twice control values. Collagen concentration was unaffected by estrogen treatment. These results indicate that estrogen treatment retards the degradation of skin collagen. (Endocrinology 93: 311, 1973)

Footnotes

¹ Supported in part by American Cancer Society Institutional Grant IN-41-A. Preliminary reports of portions of this work have appeared (1,2).

² Recipient of an Arthritis Foundation Postdoctoral Fellowship during the period of this study.

Received June 30, 1972.

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